Application | Comment | Organism |
---|---|---|
medicine | bacterial tRNA induces type I interferon and inflammatory cytokines in mouse dendritic cells and human peripheral blood mononuclear cells. tRNA from an Escherichia coli knockout strain for tRNA (Gm18)-2'-O-methyltransferase regained immunostimulatory potential. In vitro methylation of this immunostimulatory Gm18-negative tRNA with recombinant trmH from Thermus thermophilus abolishes its interferon-alpha-inducing potential. Gm18-modified tRNA acts as toll-like receptor TLR7 antagonist and blocks IFN-alpha induction of influenza A virus-infected peripheral blood mononuclear cells | Escherichia coli |
medicine | in vitro methylation of immunostimulatory Gm18-negative tRNA with recombinant trmH from Thermus thermophilus abolishes its interferon-alpha-inducing potential | Thermus thermophilus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Thermus thermophilus | - |
- |
- |