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Literature summary for 2.1.1.34 extracted from
- Aquifex aeolicus tRNA (Gm18) methyltransferase has unique substrate specificity: tRNA recognition mechanism of the enzyme (2003), J. Biol. Chem., 278, 25081-25090.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic parameters of chimeric tRNA transcripts | Aquifex aeolicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aquifex aeolicus | O67577 | subgroup of type II enzyme | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | recognition region is included within the D-arm structure of tRNA-Leu, a bulge is essentially required. 4 base pairs within the D-stem enhance methyl acceptance activity. Py16Py17G18G19 sequence is important for efficient methyl tranfer | Aquifex aeolicus | ? | - |
? |  |
| S-adenosyl-L-methionine + tRNA | - |
Aquifex aeolicus | S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanine | - |
? | |
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