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Literature summary for 2.1.1.326 extracted from

  • Kamigiri, K.; Hidaka, T.; Imai, S.; Murakami, T.; Seto, H.
    Studies on the biosynthesis of bialaphos (SF-1293) 12. C-P bond formation mechanism of bialaphos: discovery of a P-methylation enzyme (1992), J. Antibiot., 45, 781-787.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Streptomyces lividans Streptomyces hygroscopicus

Organism

Organism UniProt Comment Textmining
Streptomyces hygroscopicus
-
-
-
Streptomyces hygroscopicus SF-1293
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor
-
Streptomyces hygroscopicus S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor
-
?
2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor
-
Streptomyces hygroscopicus SF-1293 S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor
-
?
S-adenosyl-L-methionine + N-acetyldemethylbialaphos + reduced acceptor
-
Streptomyces hygroscopicus ?
-
?
S-adenosyl-L-methionine + N-acetyldemethylbialaphos + reduced acceptor
-
Streptomyces hygroscopicus SF-1293 ?
-
?

Cofactor

Cofactor Comment Organism Structure
methylcob(III)alamin methyl donor of the reaction Streptomyces hygroscopicus

General Information

General Information Comment Organism
physiological function the bacterial enzyme produces the tripeptides bialaphos and phosalacine, which inhibit plant and bacterial glutamine synthetase Streptomyces hygroscopicus