Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.321 extracted from

  • Karkhanis, V.; Wang, L.; Tae, S.; Hu, Y.J.; Imbalzano, A.N.; Sif, S.
    Protein arginine methyltransferase 7 regulates cellular response to DNA Damage by Methylating promoter histones H2A and H4 of the polymerase delta catalytic subunit gene, POLD1 (2012), J. Biol. Chem., 287, 29801-29814.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NVM4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

General Information

General Information Comment Organism
physiological function PRMT7 negatively regulates expression of genes involved in DNA repair, including ALKBH5, APEX2, POLD1, and POLD2. PRMT7 and dimethylated histones H2AR3 and H4R3are enriched at target DNA repair genes in parental cells, whereas PRMT7 knockdown causes a significant decrease in PRMT7 recruitment and H2AR3/H4R3 methylation. Decreased PRMT7 expression also results in derepression of target DNA repair genes and enhanced cell resistance to DNA-damaging agents. BRG1 colocalizes with PRMT7 on target promoters and expression of a catalytically inactive form of BRG1results in derepression of PRMT7 target DNA repair genes Homo sapiens