Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(6-bromo-9-ethyl-9H-carbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine | - |
Homo sapiens | |
2-([[2-(benzyloxy)-1,4-dihydronaphthalen-1-yl]methyl]amino)-1-phenylethan-1-ol | - |
Homo sapiens | |
7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | - |
Homo sapiens | |
dehydrosinefungin | - |
Homo sapiens | |
methyl 2-[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamido]benzoate | - |
Homo sapiens | |
N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-[(oxetan-3-yl)amino]pyrimidine-4-carboxamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14744 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-375 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MV4-11 cell | - |
Homo sapiens | - |
Th1 cell | - |
Homo sapiens | - |
Th2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PRMT5 | - |
Homo sapiens |
protein arginine methyltransferase 5 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000022 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-[(oxetan-3-yl)amino]pyrimidine-4-carboxamide | |
0.000026 | - |
pH and temperature not specified in the publication | Homo sapiens | 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | |
0.000035 | - |
pH and temperature not specified in the publication | Homo sapiens | dehydrosinefungin | |
0.00033 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl 2-[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetamido]benzoate | |
0.000517 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-(6-bromo-9-ethyl-9H-carbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine | |
0.0028 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-([[2-(benzyloxy)-1,4-dihydronaphthalen-1-yl]methyl]amino)-1-phenylethan-1-ol |
General Information | Comment | Organism |
---|---|---|
drug target | targeting PRMT5 offers a great opportunity to combat cancer in an efficient and selective way | Homo sapiens |
physiological function | the enzyme (PRMT5) is a major enzyme responsible for symmetric dimethylation of arginine residues on both histone and non-histone proteins, regulating many biological pathways in mammalian cells | Homo sapiens |