Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8CIG8 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
PRMT5 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | Loss of PRMT5 in conditional KO mice triggers an initial but transient expansion of hematopoietic stem cells. Prmt5 deletion results in a concurrent loss of hematopoietic progenitor cells, leading to fatal bone marrow aplasia. PRMT5-specific effects on hematopoiesis are cell intrinsic and depend on PRMT5 methyltransferase activity. PRMT5-deficient hematopoietic stem and progenitor cells exhibit severely impaired cytokine signaling as well as upregulation of p53 and expression of its downstream targets | Mus musculus |