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Literature summary for 2.1.1.320 extracted from

  • Liu, F.; Cheng, G.; Hamard, P.J.; Greenblatt, S.; Wang, L.; Man, N.; Perna, F.; Xu, H.; Tadi, M.; Luciani, L.; Nimer, S.D.
    Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis (2015), J. Clin. Invest., 125, 3532-3544.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q8CIG8
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Synonyms

Synonyms Comment Organism
PRMT5
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Mus musculus

General Information

General Information Comment Organism
physiological function Loss of PRMT5 in conditional KO mice triggers an initial but transient expansion of hematopoietic stem cells. Prmt5 deletion results in a concurrent loss of hematopoietic progenitor cells, leading to fatal bone marrow aplasia. PRMT5-specific effects on hematopoiesis are cell intrinsic and depend on PRMT5 methyltransferase activity. PRMT5-deficient hematopoietic stem and progenitor cells exhibit severely impaired cytokine signaling as well as upregulation of p53 and expression of its downstream targets Mus musculus