Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | D4A0E8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Rattus norvegicus | - |
brain | PRMT5 expression gradually increases throughout postnatal brain development, coinciding with the period of active myelination | Rattus norvegicus | - |
C6 glioma cell | - |
Mus musculus | - |
neuron | - |
Rattus norvegicus | - |
oligodendrocyte | - |
Rattus norvegicus | - |
oligodendrocyte | primary oligodendrocyte progenitor cell | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
PRMT5 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | siRNA-mediated depletion of PRMT5 primary oligodendrocyte progenitor cells abrogates oligodendrocyte differentiation. PRMT5-depleted oligodendrocyte progenitor and C6 glioma cells express high levels of the inhibitors of differentiation/DNA binding, Id2 and Id4, known repressors of glial cell differentiation. CpG-rich islands within the Id2 and Id4 genes are bound by PRMT5 and are hypomethylated in PRMT5-deficient cells | Mus musculus |