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Literature summary for 2.1.1.320 extracted from

  • Huang, J.; Vogel, G.; Yu, Z.; Almazan, G.; Richard, S.
    Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation (2011), J. Biol. Chem., 286, 44424-44432.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Rattus norvegicus D4A0E8
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
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Rattus norvegicus
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brain PRMT5 expression gradually increases throughout postnatal brain development, coinciding with the period of active myelination Rattus norvegicus
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C6 glioma cell
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Mus musculus
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neuron
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Rattus norvegicus
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oligodendrocyte
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Rattus norvegicus
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oligodendrocyte primary oligodendrocyte progenitor cell Mus musculus
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Synonyms

Synonyms Comment Organism
PRMT5
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Rattus norvegicus

General Information

General Information Comment Organism
physiological function siRNA-mediated depletion of PRMT5 primary oligodendrocyte progenitor cells abrogates oligodendrocyte differentiation. PRMT5-depleted oligodendrocyte progenitor and C6 glioma cells express high levels of the inhibitors of differentiation/DNA binding, Id2 and Id4, known repressors of glial cell differentiation. CpG-rich islands within the Id2 and Id4 genes are bound by PRMT5 and are hypomethylated in PRMT5-deficient cells Mus musculus