Literature summary for 2.1.1.320 extracted from

Sohail, M.; Zhang, M.; Litchfield, D.; Wang, L.; Kung, S.; Xie, J.
Differential expression, distinct localization and opposite effect on Golgi structure and cell differentiation by a novel splice variant of human PRMT5 (2015), Biochim. Biophys. Acta, 1853, 2444-2452.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	original isoform PRMT5L mainly colocalizes with Giantin, a Golgi marker	Homo sapiens	5794	-
additional information	evolutionarily emerged splice variant PRMT5S is distributed all over the cell. The isoforms are differentially expressed during neuronal or dendritic cell differentiation, and their ectopic expression shows an opposite effect on dendritic cell differentiation	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14744	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PRMT5	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	isoform PRMT5 knockdown leads to an enlarged Giantin pattern, which is prevented by the expression of either original isoform PRMT5L or evolutionary emerged splice variant PRMT5S. Rescuing PRMT5S also increases the percentage of cells with an interphase Giantin pattern compacted at one end of the nucleus, consistent with its cell cycle-arresting effect, while rescuing PRMT5L increases that of the mitotic Giantin patterns of dynamically fragmented structures. Both isoforms also similarly regulate over a thousand genes particularly those involved in apoptosis and differentiation	Homo sapiens

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Release 2023.1 (January 2023)