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Literature summary for 2.1.1.320 extracted from

  • Branscombe, T.L.; Frankel, A.; Lee, J.H.; Cook, J.R.; Yang, Z.; Pestka, S.; Clarke, S.
    PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins (2001), J. Biol. Chem., 276, 32971-32976.
    View publication on PubMed
Search for more literature for 2.1.1.320

Protein Variants

Protein Variants Comment Organism
DELTA365-369 deletion of the sequence GAGRG, residues 365-369 in the -adenosyl-L-methionine-binding motif I, leads to dramatic reduction in catalytic activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [GST-GAR]-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [GST-GAR]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [GST-GAR]-Nomega-methyl-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [GST-GAR]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H2A]-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [histone H2A]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H2A]-Nomega-methyl-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [histone H2A]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [myelin basic protein]-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [myelin basic protein]-Nomega-methyl-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega,Nomega'-dimethyl-L-arginine methylation leads to omega-NG-monomethylarginine and and symmetric omega-NG,NG-dimethylarginine residues, no formation of asymmetric dimethylarginine residues ?

Synonyms

Synonyms Comment Organism
Janus kinase-binding protein 1
-
 Homo sapiens