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Literature summary for 2.1.1.320 extracted from

  • Rho, J.; Choi, S.; Seong, Y.R.; Cho, W.K.; Kim, S.H.; Im, D.S.
    PRMT5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family (2001), J. Biol. Chem., 276, 11393-11401.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm predominant localization Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
sedimentation analysis Homo sapiens
72000
-
1 * 72000, SDS-PAGE Homo sapiens
72000
-
2 * 72000, SDS-PAGE Homo sapiens
72000
-
4 * 72000, SDS-PAGE Homo sapiens
158000
-
sedimentation analysis Homo sapiens
240000
-
sedimentation analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O14744
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information myelin basic protein methylated by PRMT5 contains monomethylated and dimethylated arginine residues Homo sapiens ?
-
?
S-adenosyl-L-methionine + [GST-fibrillarin]-L-arginine substrate is amino terminus of fibrillarin fused to glutathione S-transferase Homo sapiens S-adenosyl-L-homocysteine + [GST-fibrillarin]-Nomega-methyl-L-arginine
-
?
S-adenosyl-L-methionine + [GST-fibrillarin]-Nomega-methyl-L-arginine
-
Homo sapiens S-adenosyl-L-homocysteine + [GST-fibrillarin]-Nomega,Nomega'-dimethyl-L-arginine
-
?
S-adenosyl-L-methionine + [histone]-L-arginine
-
Homo sapiens S-adenosyl-L-homocysteine + [histone]-Nomega-methyl-L-arginine
-
?
S-adenosyl-L-methionine + [histone]-Nomega-methyl-L-arginine
-
Homo sapiens S-adenosyl-L-homocysteine + [histone]-Nomega,Nomega'-dimethyl-L-arginine
-
?
S-adenosyl-L-methionine + [myelin basic protein]-L-arginine
-
Homo sapiens S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-L-arginine
-
?
S-adenosyl-L-methionine + [myelin basic protein]-Nomega-methyl-L-arginine
-
Homo sapiens S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega,Nomega'-dimethyl-L-arginine
-
?

Subunits

Subunits Comment Organism
dimer 2 * 72000, SDS-PAGE Homo sapiens
monomer 1 * 72000, SDS-PAGE Homo sapiens
More PRMT5 forms distinct homooligomeric complexes, including a dimer and tetramer. The PRMT5 homo-oligomers are dissociated into a monomer in the presence of a reducing agent, whereas a monomer, dimer, and multimer are detected in the absence or at low concentrations of a reducing agent Homo sapiens
tetramer 4 * 72000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Skb1
-
Homo sapiens