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Literature summary for 2.1.1.319 extracted from

  • Lee, J.; Sayegh, J.; Daniel, J.; Clarke, S.; Bedford, M.T.
    PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family (2005), J. Biol. Chem., 280, 32890-32896.
    View publication on PubMed
Search for more literature for 2.1.1.319

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane isoform PRMT8 is associated with the plasma membrane due to N-terminal myristoylation Homo sapiens 5886
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NR22 isoform PRMT8
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Posttranslational Modification

Posttranslational Modification Comment Organism
additional information the N-terminal end of isoform PRMT8 harbors a myristoylation motif. PRMT8 is modified by the attachment of a myristate to the glycine residue after the initiator methionine, resulting in its association with the plasma membrane Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain PRMT8 is largely expressed in brain Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [GST-GAR protein]-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [GST-GAR protein]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [GST-GAR protein]-Nomega-methyl-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [GST-GAR protein]-Nomega,Nomega-dimethyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4]-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [histone H4]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [histone H4]-Nomega-methyl-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [histone H4]-Nomega,Nomega-dimethyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [yeast Npl3 protein]-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [yeast Npl3protein]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [yeast Npl3 protein]-Nomega-methyl-L-arginine
-
 Homo sapiens S-adenosyl-L-homocysteine + [yeast Npl3 protein]-Nomega,Nomega-dimethyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
PRMT8
-
 Homo sapiens