Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei brucei | Q57U70 | - |
- |
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 | Q57U70 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isoform PRMT6 is a type I PRMT, catalyzing the production of monomethylarginine and asymmetric dimethylarginine residues. Enzyme does not methylate several Trypanosoma brucei glycine/arginine-rich proteins tested | Trypanosoma brucei brucei | ? | - |
? | |
additional information | isoform PRMT6 is a type I PRMT, catalyzing the production of monomethylarginine and asymmetric dimethylarginine residues. Enzyme does not methylate several Trypanosoma brucei glycine/arginine-rich proteins tested | Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 | ? | - |
? | |
S-adenosyl-L-methionine + [bovine mixed histones]-L-arginine | - |
Trypanosoma brucei brucei | S-adenosyl-L-homocysteine + [bovine mixed histones]-Nomega-methyl-L-arginine | - |
? | |
S-adenosyl-L-methionine + [bovine mixed histones]-L-arginine | - |
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 | S-adenosyl-L-homocysteine + [bovine mixed histones]-Nomega-methyl-L-arginine | - |
? | |
S-adenosyl-L-methionine + [protein]-Nomega-methyl-L-arginine | - |
Trypanosoma brucei brucei | S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega-dimethyl-L-arginine | - |
? | |
S-adenosyl-L-methionine + [protein]-Nomega-methyl-L-arginine | - |
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 | S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega-dimethyl-L-arginine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PRMT6 | - |
Trypanosoma brucei brucei |
Tb927.5.3960 | - |
Trypanosoma brucei brucei |
General Information | Comment | Organism |
---|---|---|
physiological function | knockdown of isoform PRMT6 in both procyclic form and bloodstream form Trypanosoma brucei leads to a modest but reproducible effect on parasite growth in culture. Upon PRMT6 depletion, both procyclic form and bloodstream form exhibit aberrant morphologies indicating defects in cell division, and these defects differ in the two life cycle stages. PRMT6-associated proteins are histones, components of the nuclear pore complex, and flagellar proteins | Trypanosoma brucei brucei |