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Literature summary for 2.1.1.319 extracted from

  • Fisk, J.C.; Zurita-Lopez, C.; Sayegh, J.; Tomasello, D.L.; Clarke, S.G.; Read, L.K.
    TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei (2010), Eukaryot. Cell, 9, 866-877.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei brucei Q57U70
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Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 Q57U70
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform PRMT6 is a type I PRMT, catalyzing the production of monomethylarginine and asymmetric dimethylarginine residues. Enzyme does not methylate several Trypanosoma brucei glycine/arginine-rich proteins tested Trypanosoma brucei brucei ?
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?
additional information isoform PRMT6 is a type I PRMT, catalyzing the production of monomethylarginine and asymmetric dimethylarginine residues. Enzyme does not methylate several Trypanosoma brucei glycine/arginine-rich proteins tested Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 ?
-
?
S-adenosyl-L-methionine + [bovine mixed histones]-L-arginine
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Trypanosoma brucei brucei S-adenosyl-L-homocysteine + [bovine mixed histones]-Nomega-methyl-L-arginine
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?
S-adenosyl-L-methionine + [bovine mixed histones]-L-arginine
-
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 S-adenosyl-L-homocysteine + [bovine mixed histones]-Nomega-methyl-L-arginine
-
?
S-adenosyl-L-methionine + [protein]-Nomega-methyl-L-arginine
-
Trypanosoma brucei brucei S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega-dimethyl-L-arginine
-
?
S-adenosyl-L-methionine + [protein]-Nomega-methyl-L-arginine
-
Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega-dimethyl-L-arginine
-
?

Synonyms

Synonyms Comment Organism
PRMT6
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Trypanosoma brucei brucei
Tb927.5.3960
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Trypanosoma brucei brucei

General Information

General Information Comment Organism
physiological function knockdown of isoform PRMT6 in both procyclic form and bloodstream form Trypanosoma brucei leads to a modest but reproducible effect on parasite growth in culture. Upon PRMT6 depletion, both procyclic form and bloodstream form exhibit aberrant morphologies indicating defects in cell division, and these defects differ in the two life cycle stages. PRMT6-associated proteins are histones, components of the nuclear pore complex, and flagellar proteins Trypanosoma brucei brucei