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Literature summary for 2.1.1.311 extracted from

  • Sharma, S.; Yang, J.; Watzinger, P.; Koetter, P.; Entian, K.D.
    Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively (2013), Nucleic Acids Res., 41, 9062-9076.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.311

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA Saccharomyces cerevisiae the enzyme is responsible for the methylation at cytosine2278 of the 25S ribosomal RNA S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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S-adenosyl-L-methionine + cytosine2278 in 25S rRNA Saccharomyces cerevisiae ATCC 204508 the enzyme is responsible for the methylation at cytosine2278 of the 25S ribosomal RNA S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P53972
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Saccharomyces cerevisiae ATCC 204508 P53972
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA the enzyme is responsible for the methylation at cytosine2278 of the 25S ribosomal RNA Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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S-adenosyl-L-methionine + cytosine2278 in 25S rRNA the enzyme is specific for cytosine2278 of the 25S ribosomal RNA. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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 ?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA the enzyme is responsible for the methylation at cytosine2278 of the 25S ribosomal RNA Saccharomyces cerevisiae ATCC 204508 S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
-
 ?
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA the enzyme is specific for cytosine2278 of the 25S ribosomal RNA. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae Saccharomyces cerevisiae ATCC 204508 S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
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 ?

Synonyms

Synonyms Comment Organism
RCM1
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction deletion of Rcm1 specifically abolishes the methylation of m5C 2278 in the 25S rRNA. The loss of m5C2278 results in anisomycin hypersensitivity. The deletion of rcm1 does not result in any significant growth defect at 30 and 37°C. Deletion of rcm1 does not disturb the 60S stoichiometry and polysome assembly Saccharomyces cerevisiae