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Literature summary for 2.1.1.305 extracted from

  • Ramos, A.; Lombo, F.; Brana, A.F.; Rohr, J.; Mendez, C.; Salas, J.A.
    Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster (2008), Microbiology, 154, 781-788.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Streptomyces albus Streptomyces olivaceus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41180
-
x * 41180, calculated from sequence Streptomyces olivaceus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C Streptomyces olivaceus the enzyme is involved in the biosynthesis of the polyketide elloramycin S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C Streptomyces olivaceus Tü2353 the enzyme is involved in the biosynthesis of the polyketide elloramycin S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces olivaceus Q9AJU2
-
-
Streptomyces olivaceus Tü2353 Q9AJU2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C the enzyme is involved in the biosynthesis of the polyketide elloramycin Streptomyces olivaceus S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C using as biotransformation host strain EPM1 (expressing elmMI) about 24% of the precursor 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C is converted into 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C. No activity with substrates lacking the hydroxy group at C-2' (8-demethyl-8-alpha-L-oleandrosyl tetracenomycin C or 8-demethyl-8-alpha-L-olivosyl tetracenomycin C) Streptomyces olivaceus S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C the enzyme is involved in the biosynthesis of the polyketide elloramycin Streptomyces olivaceus Tü2353 S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C using as biotransformation host strain EPM1 (expressing elmMI) about 24% of the precursor 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C is converted into 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C. No activity with substrates lacking the hydroxy group at C-2' (8-demethyl-8-alpha-L-oleandrosyl tetracenomycin C or 8-demethyl-8-alpha-L-olivosyl tetracenomycin C) Streptomyces olivaceus Tü2353 S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?

Subunits

Subunits Comment Organism
? x * 41180, calculated from sequence Streptomyces olivaceus

Synonyms

Synonyms Comment Organism
ElmMI
-
Streptomyces olivaceus

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of the polyketide elloramycin Streptomyces olivaceus