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Literature summary for 2.1.1.288 extracted from

  • Dickens, M.L.; Ye, J.; Strohl, W.R.
    Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5 (1995), J. Bacteriol., 177, 536-543.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
the dauC gene, encoding aklanonic acid methyltransferase, complements dauC-blocked mutants of Streptomyces sp. strain C5, restores in vitro aklanonic acid methyltransferase activities to the mutant strains, and confers in vitro aklanonic acid methyltransferase activity on Streptomyces lividans Streptomyces sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
2 * 24000, SDS-PAGE Streptomyces sp.
24319
-
2 * 24319, SDS-PAGE Streptomyces sp.
48000
-
gel filtration Streptomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + aklanonate Streptomyces sp. the enzyme is involved in daunomycin biosynthesis S-adenosyl-L-homocysteine + methyl aklanonate
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces sp. Q55214
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Streptomyces sp.

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Streptomyces sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + aklanonate
-
Streptomyces sp. S-adenosyl-L-homocysteine + methyl aklanonate
-
?
S-adenosyl-L-methionine + aklanonate the enzyme is involved in daunomycin biosynthesis Streptomyces sp. S-adenosyl-L-homocysteine + methyl aklanonate
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 24000, SDS-PAGE Streptomyces sp.
homodimer 2 * 24319, SDS-PAGE Streptomyces sp.

Synonyms

Synonyms Comment Organism
AAMT
-
Streptomyces sp.
aklanonate methyltransferase
-
Streptomyces sp.
DauC
-
Streptomyces sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Streptomyces sp.

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of the anthracycline daunorubicin Streptomyces sp.