Literature summary for 2.1.1.28 extracted from

Cleary, S.; Brouwers, F.M.; Eisenhofer, G.; Pacak, K.; Christie, D.L.; Lipski, J.; McNeil, A.R.; Phillips, J.K.
Expression of the noradrenaline transporter and phenylethanolamine N-methyltransferase in normal human adrenal gland and phaeochromocytoma (2005), Cell Tissue Res., 322, 443-453.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	immunohistochemical analysis in normal human medulla shows a expression of phenylethanolamine N-methyltransferase localized to the cytoplasm. All tyrosine hydroxylase-positive cells contain phenylethanolamine N-methyltransferase. All normal human chromaffin cells also strongly express noradrenaline transporter, which is always colocalized with phenylethanolamine N-methyltransferase. Double-labeling experiments on phaeochromocytoma tissue reveals, that the expression of phenylethanolamine N-methyltransferase is variable, ranging from strong to weak to absent. The immunohistochemical detection of phenylethanolamine N-methyltransferase correlates with the presence of adrenaline in all but one sample (but the intensitiy levels do not correlate). In human phaeochromocytomas the expression of the noradrenaline transporter is not consistently co-localized with phenylethanolamine N-methyltransferase.	-
Rattus norvegicus	-	Wistar rats, 6-12 weeks, either sex. In the immunohistochemistry experiment phenylethanolamine N-methyltransferase demonstrate strong staining in the majority of cells, representing the adrenergic cell population.	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chromaffin cell	-	Homo sapiens	-
chromaffin cell	-	Rattus norvegicus	-
pheochromocytoma cell	neuroendocrine tumour of chromaffin cells	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PNMT	-	Homo sapiens
PNMT	-	Rattus norvegicus

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Release 2023.1 (January 2023)