Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines | several 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines and some enantiomers of 3-trifuoromethyl-1,2,3,4-tetrahydroisoquinolines. For the phenylethanolamine N-methyltransferase inhibitory potency of different 3-trifuoromethyl-1,2,3,4-tetrahydroisoquinolines, compounds bearing a lipophilic 7-substituent show higher potency than compounds bearing a hydrophilic 7-substituent. Comparison to the inhibitory activity of the entantiomers of the most potent racemates show that the R-enantiomers are approximately 4fold as potent as their corresponding S-enantiomers. | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
the phenylethanolamine N-methyltransferase inhibitory potency of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline is lower than the of other 1,2,3,4-tetrahydroisoquinolines, some of them show good selectivity due to their extremely low alpha2-adrenoceptor affinity | - |
Synonyms | Comment | Organism |
---|---|---|
PNMT | - |
Homo sapiens |