Literature summary for 2.1.1.28 extracted from

Grunewald, G.L.; Romero, F.A.; Seim, M.R.; Criscione, K.R.; Deupree, J.D.; Spackman, C.C.; Bylund, D.B.
Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines (2005), Bioorg. Med. Chem. Lett., 15, 1143-1147.

Search for more literature for 2.1.1.28

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-hydroxyethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
3-hydroxyethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
3-hydroxypropyl-7-bromo-1,2,3,4-tetrahydroisoquinoline	extension of the 3-hydroxyalkyl chain by just one carbon results in a significant loss in phenylethanolamine N-methyltransferse inhibitory potency	Homo sapiens
3-hydroxypropyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	extension of the 3-hydroxyalkyl chain by just one carbon results in a significant loss in phenylethanolamine N-methyltransferse inhibitory potency	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00035	-	3-hydroxyethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
0.00051	-	3-hydroxyethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
0.0014	-	3-hydroxypropyl-7-nitro-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
0.0017	-	3-hydroxypropyl-7-bromo-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)