Literature summary for 2.1.1.28 extracted from

Wu, Q.; Criscione, K.R.; Grunewald, G.L.; McLeish, M.J.
Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data (2004), Bioorg. Med. Chem. Lett., 14, 4217-4220.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(R)-7-bromo-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
1-(2,3-dichlorophenyl)ethanamine	-	Homo sapiens
3-fluoromethyl-7-iodo-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
7-sulfonamido-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens
8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine	-	Homo sapiens
N-(4-chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	-	Homo sapiens
R-(+)-7-bromo-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000031	-	7,8-dichloro-1,2,3,4-tetrahydroisoquinoline	pH 8.0	Homo sapiens
0.0000049	-	R-(+)-7-bromo-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline	pH 8.0	Homo sapiens
0.000012	-	8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine	pH 8.0	Homo sapiens
0.000073	-	3-fluoromethyl-7-iodo-1,2,3,4-tetrahydroisoquinoline	pH 8.0	Homo sapiens
0.00009	-	1-(2,3-dichlorophenyl)ethanamine	pH 8.0	Homo sapiens
0.00027	-	N-(4-chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	pH 8.0	Homo sapiens
0.00028	-	7-sulfonamido-1,2,3,4-tetrahydroisoquinoline	pH 8.0	Homo sapiens

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Release 2023.1 (January 2023)