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Literature summary for 2.1.1.28 extracted from

  • Hoffman, A.R.; Ciaranello, R.D.; Axelrod, J.
    Substrate and inhibitor kinetics of bovine phenylethanolamine-N-methyltransferase (1975), Biochem. Pharmacol., 24, 544-546.
    View publication on PubMed
Search for more literature for 2.1.1.28

Inhibitors

Inhibitors Comment Organism Structure
dopamine competitive inhibition with respect to phenylethanolamine Bos taurus
epinephrine noncompetitive with normetanephrine as substrate Bos taurus
norepinephrine noncompetitive inhibition with phenylethanolamine as substrate, competitive inhibition with normetanephrine as substrate Bos taurus
Phenylethylamine competitive inhibition with respect to phenylethanolamine Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Bos taurus
-
adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dopamine + S-adenosyl-L-methionine
-
 Bos taurus ? + S-adenosyl-L-homocysteine
-
 ?
epinephrine + S-adenosyl-L-methionine
-
 Bos taurus ? + D-adenosylhomocysteine
-
 ?
norepinephrine + S-adenosyl-L-methionine
-
 Bos taurus epinephrine + S-adenosyl-L-homocysteine
-
 ?
phenylethanolamine + S-adenosyl-L-methionine
-
 Bos taurus N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0059
-
 norepinephrine noncompetitive with phenylethanolamine Bos taurus
3.6
-
 Phenylethylamine competitive with phenylethanolamine Bos taurus
8
-
 dopamine competitive with phenylethanolamine Bos taurus