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Literature summary for 2.1.1.262 extracted from

  • Niehaus, T.D.; Kinison, S.; Okada, S.; Yeo, Y.S.; Bell, S.A.; Cui, P.; Devarenne, T.P.; Chappell, J.
    Functional identification of triterpene methyltransferases from Botryococcus braunii race B (2012), J. Biol. Chem., 287, 8163-8173.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of TMT-1 and TMT-2 in Saccharomyces cerevisiae microsomes leading to mono- and dimethylated products, co-expression of various TMT and SMT-like genes in Saccharomyces cerevisiae strain TN-7 Botryococcus braunii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis-Menten enzyme kinetics for TMT-1 and TMT-2 Botryococcus braunii

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Botryococcus braunii 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + squalene Botryococcus braunii overall reaction 2 S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene
-
ir
2 S-adenosyl-L-methionine + squalene Botryococcus braunii race B overall reaction 2 S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene
-
ir
S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene Botryococcus braunii
-
S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene
-
?
S-adenosyl-L-methionine + squalene Botryococcus braunii
-
S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene
-
?

Organism

Organism UniProt Comment Textmining
Botryococcus braunii
-
-
-
Botryococcus braunii race B
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.56
-
recombinant TMT-1, pH 7.5, 37°C Botryococcus braunii
143.7
-
recombinant TMT-2, pH 7.5, 37°C Botryococcus braunii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + squalene overall reaction Botryococcus braunii 2 S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene
-
ir
2 S-adenosyl-L-methionine + squalene overall reaction Botryococcus braunii race B 2 S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene
-
ir
additional information mono- and dimethylated products with terminal carbon C-3 as the atomic acceptor sites for the methyl additions to squalene, NMR analysis, overview TMT-1 and TMT-2 show only low activity with C30 botryococcene Botryococcus braunii ?
-
?
additional information mono- and dimethylated products with terminal carbon C-3 as the atomic acceptor sites for the methyl additions to squalene, NMR analysis, overview TMT-1 and TMT-2 show only low activity with C30 botryococcene Botryococcus braunii race B ?
-
?
S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene
-
Botryococcus braunii S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene
-
?
S-adenosyl-L-methionine + squalene
-
Botryococcus braunii S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene
-
?

Synonyms

Synonyms Comment Organism
triterpene methyltransferase
-
Botryococcus braunii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Botryococcus braunii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Botryococcus braunii

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Botryococcus braunii

General Information

General Information Comment Organism
metabolism TMT-1 and TMT-2 exhibit preference for squalene as the methyl acceptor substrate Botryococcus braunii