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Literature summary for 2.1.1.257 extracted from

  • Wurm, J.; Meyer, B.; Bahr, U.; Held, M.; Frolow, O.; Koetter, P.; Engels, J.; Heckel, A.; Karas, M.; Entian, K.; Woehnert, J.
    The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase (2010), Nucleic Acids Res., 38, 2387-2398.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.257

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92979
-
-
Methanocaldococcus jannaschii Q57977
-
-
Methanocaldococcus jannaschii DSM 2661 Q57977
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificity analysis by NMR binding and affinity study for RNA, overview. The enzyme is highly specific for pseudouridine. Methanocaldococcus jannaschii Nep1 binds to the yeast Nep1 RNA consensus sequence Methanocaldococcus jannaschii ?
-
 ?
additional information substrate specificity analysis by NMR binding and affinity study for RNA, overview. The enzyme is highly specific for pseudouridine. Methanocaldococcus jannaschii Nep1 binds to the yeast Nep1 RNA consensus sequence Methanocaldococcus jannaschii DSM 2661 ?
-
 ?
S-adenosyl-L-methionine + pseudouridine in 5'-GAUPsiCAACGCC-3'
-
 Methanocaldococcus jannaschii S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-GAUmethylPsiCAACGCC-3'
-
 ?
S-adenosyl-L-methionine + pseudouridine in 5'-GAUPsiCAACGCC-3'
-
 Methanocaldococcus jannaschii DSM 2661 S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-GAUmethylPsiCAACGCC-3'
-
 ?
S-adenosyl-L-methionine + pseudouridine in 5'-PsiCAACGCC-3'
-
 Methanocaldococcus jannaschii S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-methylPsiCAACGCC-3'
-
 ?
S-adenosyl-L-methionine + pseudouridine in 5'-PsiCAACGCC-3'
-
 Methanocaldococcus jannaschii DSM 2661 S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-methylPsiCAACGCC-3'
-
 ?
S-adenosyl-L-methionine + pseudouridine in 5'-UPsiCAACGC--3'
-
 Methanocaldococcus jannaschii S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-UmethylPsiCAACGC--3'
-
 ?
S-adenosyl-L-methionine + pseudouridine in 5'-UPsiCAACGC--3'
-
 Methanocaldococcus jannaschii DSM 2661 S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-UmethylPsiCAACGC--3'
-
 ?
S-adenosyl-L-methionine + pseudouridine in 5'-UPsiCAACGCC-3'
-
 Methanocaldococcus jannaschii S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-UmethylPsiCAACGCC-3'
-
 ?
S-adenosyl-L-methionine + pseudouridine in 5'-UPsiCAACGCC-3'
-
 Methanocaldococcus jannaschii DSM 2661 S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-UmethylPsiCAACGCC-3'
-
 ?

Subunits

Subunits Comment Organism
dimer Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases Homo sapiens
dimer Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases Methanocaldococcus jannaschii

Synonyms

Synonyms Comment Organism
Emg1
-
 Homo sapiens
MjNep1
-
 Methanocaldococcus jannaschii
Nep1
-
 Homo sapiens
Nep1
-
 Methanocaldococcus jannaschii
pseudouridine-N1-specific methyltransferase
-
 Homo sapiens
pseudouridine-N1-specific methyltransferase
-
 Methanocaldococcus jannaschii
ribosome assembly factor Nep1
-
 Homo sapiens
ribosome assembly factor Nep1
-
 Methanocaldococcus jannaschii

General Information

General Information Comment Organism
evolution Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases Homo sapiens
evolution Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases Methanocaldococcus jannaschii
malfunction a mutation in the human Nep1 homolog causes Bowen-Conradi syndrome, a severe developmental disorder Homo sapiens
physiological function Nep1 acts as a methyltransferase in ribosome biogenesis Homo sapiens
physiological function Nep1 acts as a methyltransferase in ribosome biogenesis Methanocaldococcus jannaschii