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Literature summary for 2.1.1.247 extracted from

  • Hoeppner, A.; Thomas F, Rueppel, A.; Hensel, R.; Blankenfeldt W, Bayer P, Faust A.
    Structure of the corrinoid:coenzyme M methyltransferase MtaA from Methanosarcina mazei (2012), Acta Crystallogr. Sect. D, 68, 1549-1557.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Methanosarcina mazei

Crystallization (Commentary)

Crystallization (Comment) Organism
crystals of His6-tagged MtaA are obtained at room temperature by the hanging-drop vapour-diffusion method. Hexagonal-shaped crystals of the selenomethionine derivative are obtained by the sitting-drop vapour-diffusion method. The crystal structures of MtaA in a substrate-free but Zn2+-bound state and in complex with Zn2+ and coenzyme M (HS-CoM) are reported at resolutions of 1.8 and 2.1 A Methanosarcina mazei

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ the Zn2+ ion in the active site of MtaA is coordinated tetrahedrally via His240, Cys242 and Cys319. In the substrate-free form the fourth ligand is Glu263 Methanosarcina mazei

Organism

Organism UniProt Comment Textmining
Methanosarcina mazei Q8PXZ6
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Methanosarcina mazei DSM 3647 Q8PXZ6
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Synonyms

Synonyms Comment Organism
corrinoid:coenzyme M methyltransferase
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Methanosarcina mazei
MM_1070 locus name Methanosarcina mazei
mtaA
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Methanosarcina mazei