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Literature summary for 2.1.1.233 extracted from

  • Longman, M.; Ranieri, A.; Avkiran, M.; Snabaitis, A.
    Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes (2014), PLoS ONE, 9, e86234.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.233

Activating Compound

Activating Compound Comment Organism Structure
additional information stimulation of Gi-coupled adenosine type 1 receptors with N6-cyclopentyladenosine, and of other Gi-coupled receptors such as muscarinic M2 receptors (stimulated with carbachol) and angiotensin II AT2 receptors (stimulated with CGP42112) in adult rat ventricular myocytes, specifically induces methyltransferase LCMT-1 for PP2AC carboxylmethylation at Leu309 in a concentration-dependent manner. PI3K activity is upregulated in response to adenosine type 1 receptor stimulation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm predominantly Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309 Rattus norvegicus
-
 S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester
-
 ?
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309 Rattus norvegicus Wistar
-
 S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q6P4Z6
-
-
Rattus norvegicus Wistar Q6P4Z6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte ventricular Rattus norvegicus
-
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309
-
 Rattus norvegicus S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester
-
 ?
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine309
-
 Rattus norvegicus Wistar S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine309 methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
LCMT-1
-
 Rattus norvegicus
leucine carboxylmethyltransferase-1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the enzyme regulates the activity and subcellular localisation of type 2A protein phosphatase, PP2A, by reversible carboxylmethylation of its C-terminal leucine 309 residue. Stimulation of adenosine type 1 receptors induces PP2AC carboxylmethylation via PI3K and alters subcellular distribution in adult rat ventricular myocytes Rattus norvegicus