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Literature summary for 2.1.1.233 extracted from

  • Lee, J.; Pallas, D.
    Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells (2007), J. Biol. Chem., 282, 30974-30984.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.233

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
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 Homo sapiens
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HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine
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 Mus musculus S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
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 ?
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine
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 Homo sapiens S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
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 ?

Synonyms

Synonyms Comment Organism
LCMT-1
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 Mus musculus
LCMT-1
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 Homo sapiens
leucine carboxy methyltransferase-1
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 Mus musculus
leucine carboxy methyltransferase-1
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 Homo sapiens

General Information

General Information Comment Organism
malfunction homozygous gene trap knock-out of leucine carboxyl methyltransferase-1 in mice results in embryonic lethality Mus musculus
malfunction leucine carboxyl methyltransferase-1 (LCMT-1) knockdown reduces the formation of protein phosphatase 2A heterotrimers containing the Balpha regulatory subunit and, in a subset of the cells, induces apoptosis, characterized by caspase activation, nuclear condensation/fragmentation, and membrane blebbing. LCMT-1 knockdown cells are more sensitive to the spindle-targeting drug nocodazole Homo sapiens
physiological function leucine carboxyl methyltransferase-1 (LCMT-1) is essential for embryonic development in mice. LCMT-1 is important for spindle checkpoint Mus musculus
physiological function leucine carboxyl methyltransferase-1 (LCMT-1) is necessary for normal progression through mitosis and cell survival. LCMT-1 is important for spindle checkpoint Homo sapiens