Literature summary for 2.1.1.229 extracted from

Begley, U.; Dyavaiah, M.; Patil, A.; Rooney, J.P.; DiRenzo, D.; Young, C.M.; Conklin, D.S.; Zitomer, R.S.; Begley, T.J.
Trm9-catalyzed tRNA modifications link translation to the DNA damage response (2007), Mol. Cell, 28, 860-870.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + carboxymethyluridine34 in tRNA	Saccharomyces cerevisiae	Trm9 methylates the uridine wobble base of tRNAArg(UCU) and tRNAGlU(UUC)	S-adenosyl-L-homocysteine + 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P49957	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + carboxymethyluridine34 in tRNA	Trm9 methylates the uridine wobble base of tRNAArg(UCU) and tRNAGlU(UUC)	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA	-	?

Synonyms

Synonyms	Comment	Organism
Trm9	-	Saccharomyces cerevisiae
tRNA methyltransferase 9	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	Trm9 prevents cell death via translational enhancement of DNA damage response proteins. Trm9-specific tRNA modifications enhance codon-specific translation elongation and promote increased levels of key damage response proteins	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)