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Literature summary for 2.1.1.222 extracted from

  • Poon, W.W.; Barkovich, R.J.; Hsu, A.Y.; Frankel, A.; Lee, P.T.; Sheperd, J.N.; Myles, D.C.; Clarke, C.F.
    Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis (1999), J. Biol. Chem., 274, 21665-21672.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion the Coq3 polypeptide is peripherally associated with the matrix side of the inner membrane of yeast mitochondria Saccharomyces cerevisiae 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae, 1. the methylation of 3,4-dihydroxy-5-hexaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-6 (this reaction is classified as EC 2.1.1.64) ?
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?
additional information Rattus norvegicus the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-9 in Rattus norvegicus, 1. the methylation of 3,4-dihydroxy-5-nonaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-9 (this reaction is classified as EC 2.1.1.64) ?
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?
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol Escherichia coli the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3-(all-trans-octaprenyl)benzene-1,2-diol and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64) S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Rattus norvegicus Q63159
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Saccharomyces cerevisiae P27680
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Purification (Commentary)

Purification (Comment) Organism
His6-UbiG fusion protein Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae, 1. the methylation of 3,4-dihydroxy-5-hexaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-6 (this reaction is classified as EC 2.1.1.64) Saccharomyces cerevisiae ?
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?
additional information the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-9 in Rattus norvegicus, 1. the methylation of 3,4-dihydroxy-5-nonaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-9 (this reaction is classified as EC 2.1.1.64) Rattus norvegicus ?
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?
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol Escherichia coli S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol ?
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli Rattus norvegicus S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol ?
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 2-methoxy-6-(farnesyl)phenol i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol ?
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol
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Escherichia coli S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
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?
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3-(all-trans-octaprenyl)benzene-1,2-diol and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64) Escherichia coli S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol
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?

Synonyms

Synonyms Comment Organism
UbiG
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Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
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assay at Escherichia coli
7
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assay at Saccharomyces cerevisiae
7
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assay at Rattus norvegicus