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Literature summary for 2.1.1.220 extracted from

  • Guelorget, A.; Barraud, P.; Tisne, C.; Golinelli-Pimpaneau, B.
    Structural comparison of tRNA m(1)A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions (2011), BMC Struct. Biol., 11, 48.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
ligand-free TrmI, X-ray diffraction structure determination and analysis at 1.65 A resolution Thermotoga maritima
TrmI complexed with S-adenosyl-L-methionine, X-ray diffraction structure determination and analysis at 1.98 A resolution Mycobacterium tuberculosis
TrmI complexed with S-adenosyl-L-methionine, X-ray diffraction structure determination and analysis at 2.2 A resolution Aquifex aeolicus
TrmI protein complexed as tetramer with S-adenosyl-L-homocysteine or as monomer with S-adenosyl-L-methionine, X-ray diffraction structure determination and analysis at 2.05-2.6 A or 1.6 A resolution, respectively Pyrococcus abyssi
TrmI protein complexed with S-adenosyl-L-homocysteine, X-ray diffraction structure determination and analysis at 1.7 A resolution Thermus thermophilus
TrmI-61 protein complexed with S-adenosyl-L-methionine, X-ray diffraction structure determination and analysis at 2.5 A resolution Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine58 in tRNA Thermus thermophilus tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA Homo sapiens tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA Saccharomyces cerevisiae tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA Mycobacterium tuberculosis tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA Thermotoga maritima tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA Aquifex aeolicus tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA Pyrococcus abyssi tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?

Organism

Organism UniProt Comment Textmining
Aquifex aeolicus
-
-
-
Homo sapiens
-
gene TRM61 encoding subunit TrmI-61
-
Mycobacterium tuberculosis
-
-
-
Pyrococcus abyssi
-
-
-
Saccharomyces cerevisiae
-
-
-
Thermotoga maritima
-
-
-
Thermus thermophilus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine58 in tRNA
-
Thermus thermophilus S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA
-
Homo sapiens S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA
-
Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA
-
Mycobacterium tuberculosis S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA
-
Thermotoga maritima S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA
-
Aquifex aeolicus S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA
-
Pyrococcus abyssi S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs Thermus thermophilus S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs Homo sapiens S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs Mycobacterium tuberculosis S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs Thermotoga maritima S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs Aquifex aeolicus S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?
S-adenosyl-L-methionine + adenine58 in tRNA tRNA m1A58 methyltransferase, TrmI, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs Pyrococcus abyssi S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
-
?

Subunits

Subunits Comment Organism
heterotetramer dimers of tightly assembled heterodimers, formed by TrmI-6 and TrmI-61 subunits, interactions and structure analysis, overview Homo sapiens
More comparative structural analysis of TrmIs, overview Thermus thermophilus
More comparative structural analysis of TrmIs, overview Homo sapiens
More comparative structural analysis of TrmIs, overview Saccharomyces cerevisiae
More comparative structural analysis of TrmIs, overview Mycobacterium tuberculosis
More comparative structural analysis of TrmIs, overview Thermotoga maritima
More comparative structural analysis of TrmIs, overview Aquifex aeolicus
More comparative structural analysis of TrmIs, overview Pyrococcus abyssi
tetramer dimers of tightly assembled dimers, bacterial enzymes from thermophilic organisms display additional intermolecular ionic interactions across the dimer interfaces, interactions and structure analysis, overview Thermus thermophilus
tetramer dimers of tightly assembled dimers, bacterial enzymes from thermophilic organisms display additional intermolecular ionic interactions across the dimer interfaces, interactions and structure analysis, overview Thermotoga maritima
tetramer dimers of tightly assembled dimers, hyperthermophilic enzymes present additional hydrophobic contacts at the dimer interfaces, and the tetramer is strengthened by four intersubunit disulfide bridges, interactions and structure analysis, overview Pyrococcus abyssi
tetramer dimers of tightly assembled dimers, hyperthermophilic enzymes present additional hydrophobic contacts at the dimer interfaces, interactions and structure analysis, overview Aquifex aeolicus
tetramer dimers of tightly assembled dimers, interactions and structure analysis, overview Saccharomyces cerevisiae
tetramer dimers of tightly assembled dimers, interactions and structure analysis, overview Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
m1A58 MTase
-
Thermus thermophilus
m1A58 MTase
-
Homo sapiens
m1A58 MTase
-
Saccharomyces cerevisiae
m1A58 MTase
-
Mycobacterium tuberculosis
m1A58 MTase
-
Thermotoga maritima
m1A58 MTase
-
Aquifex aeolicus
m1A58 MTase
-
Pyrococcus abyssi
Rv2118c
-
Mycobacterium tuberculosis
TrmI
-
Thermus thermophilus
TrmI
-
Homo sapiens
TrmI
-
Saccharomyces cerevisiae
TrmI
-
Mycobacterium tuberculosis
TrmI
-
Thermotoga maritima
TrmI
-
Aquifex aeolicus
TrmI
-
Pyrococcus abyssi
tRNA m1A58 methyltransferase
-
Thermus thermophilus
tRNA m1A58 methyltransferase
-
Homo sapiens
tRNA m1A58 methyltransferase
-
Saccharomyces cerevisiae
tRNA m1A58 methyltransferase
-
Mycobacterium tuberculosis
tRNA m1A58 methyltransferase
-
Thermotoga maritima
tRNA m1A58 methyltransferase
-
Aquifex aeolicus
tRNA m1A58 methyltransferase
-
Pyrococcus abyssi

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Thermus thermophilus
S-adenosyl-L-methionine
-
Homo sapiens
S-adenosyl-L-methionine
-
Saccharomyces cerevisiae
S-adenosyl-L-methionine
-
Mycobacterium tuberculosis
S-adenosyl-L-methionine
-
Thermotoga maritima
S-adenosyl-L-methionine
-
Aquifex aeolicus
S-adenosyl-L-methionine
-
Pyrococcus abyssi

General Information

General Information Comment Organism
evolution comparative structural analysis of TrmIs from archea, prokaryota, and eukaryota, overview Thermus thermophilus
evolution comparative structural analysis of TrmIs from archea, prokaryota, and eukaryota, overview Homo sapiens
evolution comparative structural analysis of TrmIs from archea, prokaryota, and eukaryota, overview Saccharomyces cerevisiae
evolution comparative structural analysis of TrmIs from archea, prokaryota, and eukaryota, overview Mycobacterium tuberculosis
evolution comparative structural analysis of TrmIs from archea, prokaryota, and eukaryota, overview Thermotoga maritima
evolution comparative structural analysis of TrmIs from archea, prokaryota, and eukaryota, overview Aquifex aeolicus
evolution comparative structural analysis of TrmIs from archea, prokaryota, and eukaryota, overview Pyrococcus abyssi
physiological function tRNA m1A58 methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs Mycobacterium tuberculosis
physiological function tRNA m1A58 methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs, a modification, that is essential for cell growth at high temperatures Thermus thermophilus
physiological function tRNA m1A58 methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs, a modification, that is essential for cell growth at high temperatures Thermotoga maritima
physiological function tRNA m1A58 methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs, a modification, that is essential for cell growth at high temperatures Aquifex aeolicus
physiological function tRNA m1A58 methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs, a modification, that is essential for cell growth at high temperatures Pyrococcus abyssi
physiological function tRNA m1A58 methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs, a modification, that is essential for cell growth in yeast Homo sapiens
physiological function tRNA m1A58 methyltransferase catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to N1 of adenine 58 in the T-loop of tRNAs, a modification, that is essential for cell growth in yeast Saccharomyces cerevisiae