Literature summary for 2.1.1.209 extracted from

Treede, I.; Jakobsen, L.; Kirpekar, F.; Vester, B.; Weitnauer, G.; Bechthold, A.; Douthwaite, S.
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose (2003), Mol. Microbiol., 49, 309-318.

Search for more literature for 2.1.1.209

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + guanine2535 in 23S rRNA	Streptomyces viridochromogenes	AviRa modifies guanine2353 within helix 91 of 23S rRNA	S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces viridochromogenes	Q9F5K5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + guanine2535 in 23S rRNA	AviRa modifies guanine2353 within helix 91 of 23S rRNA	Streptomyces viridochromogenes	S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA	-	?
S-adenosyl-L-methionine + guanine2535 in 23S rRNA	AviRa modifies guanine2353 within helix 91 of 23S rRNA. The exact position of the modification is conformed by MALDI mass spectrometry, a single methyl group is added. No methylation activity with 16S rRNA	Streptomyces viridochromogenes	S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA	-	?

Synonyms

Synonyms	Comment	Organism
AviRa	-	Streptomyces viridochromogenes

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Streptomyces viridochromogenes

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Streptomyces viridochromogenes

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)