Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-aza-2'-deoxycytidine | the catalytic mechanism is disrupted by the suicide inhibitor | Homo sapiens | |
5-azacytidine | the catalytic mechanism is disrupted by the suicide inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | DNMT2 functions primarily, if not exclusively, as a cytosine 5-methylation RNA methyltransferase with three verified tRNA targets: tRNAAsp, tRNAGly and tRNAVal | ? | - |
? | |
S-adenosyl-L-methionine + cytosine38 in tRNAAsp precursor | Homo sapiens | - |
S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp precursor | - |
? | |
S-adenosyl-L-methionine + cytosine38 in tRNAGly precursor | Homo sapiens | - |
S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGly precursor | - |
? | |
S-adenosyl-L-methionine + cytosine38 in tRNAVal precursor | Homo sapiens | - |
S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAVal precursor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + cytosine38 in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNA | the enzyme forms a covalent enzyme-substrate intermediate with its target | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | DNMT2 functions primarily, if not exclusively, as a cytosine 5-methylation RNA methyltransferase with three verified tRNA targets: tRNAAsp, tRNAGly and tRNAVal | Homo sapiens | ? | - |
? | |
additional information | development and evaluation of 5-azacytidine-mediated RNA immunoprecipitation, a mechanism-based technique in nine steps that exploits the covalent bond formed between an RNA methyltransferase and the cytidine analogue 5-azacytidine to recover RNA targets by immunoprecipitation, overview. High frequency of C>G transversions at the cytosine residues targeted by the enzyme, allowing identification of the specific methylated cytosine(s) in target RNAs. tRNAGly(GCC) bears one DNMT2 target site (C38) | Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + cytosine38 in tRNAAsp precursor | - |
Homo sapiens | S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAAsp precursor | - |
? | |
S-adenosyl-L-methionine + cytosine38 in tRNAGly precursor | - |
Homo sapiens | S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAGly precursor | - |
? | |
S-adenosyl-L-methionine + cytosine38 in tRNAVal precursor | - |
Homo sapiens | S-adenosyl-L-homocysteine + 5-methylcytosine38 in tRNAVal precursor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dnmt2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the DNMT2 family of cytosine 5-methylation-RNA methyltransferases utilizing only one cysteine in their catalytic pocket | Homo sapiens |