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Literature summary for 2.1.1.204 extracted from
- The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis (2008), PLoS One, 3, e1414.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | Dnmt2 is both a cytoplasmic and a nuclear protein | Drosophila melanogaster | 5737 | - |
| nucleus | Dnmt2 is both a cytoplasmic and a nuclear protein. A significant amount of Dnmt2 is bound to the nuclear matrix. Dnmt2-EGFP(enhanced-green-fluorescent-protein) enters prophase nuclei and shows a spindle-like localization pattern during mitotic divisions. This localization is microtubule dependent. Dnmt2 can access DNA during mitotic cell divisions | Drosophila melanogaster | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blastocyst | - |
Drosophila melanogaster | - |
| embryo | ubiquitously expressed during early embryogenesis. Expression remains ubiquitous throughout development with enrichment in the foregut and hindgut as well as in the developing mesoderm in gastrulating embryos. Dnmt2 proteins are enriched in actively dividing cells. Dnmt2 localization is highly dynamic during the cell cycle | Drosophila melanogaster | - |
| germ cell | Dnmt2-EGFP is highly expressed in the germarium, blastocyst and cyst stages of the female germ line with the exception of follicle cells. Dnmt2-EGFP is mostly present in the cytoplasm but can also be found in nurse cell nuclei. In the male germ line, Dnmt2-EGFP is expressed in most cells, including stem cells as well as in maturing spermatocytes with the exception of the post-mitotic hub cells | Drosophila melanogaster | - |
| germarium | - |
Drosophila melanogaster | - |
| nurse cell | - |
Drosophila melanogaster | - |
| ovary | - |
Drosophila melanogaster | - |
| salivary gland cell line | - |
Drosophila melanogaster | - |
| spermatocyte | - |
Drosophila melanogaster | - |
| testis | - |
Drosophila melanogaster | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dnmt2 | - |
Drosophila melanogaster |
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