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Literature summary for 2.1.1.20 extracted from

  • Chou, W.Y.; Zhao, J.F.; Chen, Y.M.; Lee, K.I.; Su, K.H.; Shyue, S.K.; Lee, T.S.
    Role of glycine N-methyltransferase in experimental ulcerative colitis (2014), J. Gastroenterol. Hepatol., 29, 494-501.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
colon GNMT is expressed in the epithelium of the colon under normal conditions, and with dextran sulfate sodium treatment, its expression is predominant in infiltrated leukocytes of lesions Mus musculus
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leukocyte GNMT is expressed in the epithelium of the colon under normal conditions, and with dextran sulfate sodium treatment, its expression is predominant in infiltrated leukocytes of lesions Mus musculus
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General Information

General Information Comment Organism
physiological function mice with genetic deletion of GNMT show increased susceptibility to dextran sulfate sodium induction of colitis. Severe colonic inflammation, including increased crypt loss, leukocyte infiltration, and hemorrhage, are greater with dextran sulfate sodium treatment in GNMT?/? than wild-type mice. The expression of adhesion molecule and inflammatory mediators in the colon is significantly higher with dextran sulfate sodium treatment in GNMT?/? than wild-type mice. Loss of GNMT decreases cell apoptosis in colitis lesions with dextran sulfate sodium treatment Mus musculus