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Literature summary for 2.1.1.2 extracted from
- Reversible inactivation of recombinant rat liver guanidinoacetate methyltransferase by glutathione disulfide (1991), Arch. Biochem. Biophys., 289, 90-96.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | readily reactivated by reduced glutathione, substrates do not protect against inactivation, guanidinoacetate together with sinefungin protects against inactivation, can be reactivated with thiol compounds | Rattus norvegicus |  |
| sinefungin | competitive with S-adenosylmethionine | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanidinoacetate | Rattus norvegicus | - |
S-adenosyl-L-homocysteine + creatine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
expressed in Escherichia coli | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + guanidinoacetate | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + creatine | - |
? | |
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Release 2023.1 (January 2023)
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