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Literature summary for 2.1.1.190 extracted from
- Mutagenesis of the modified bases, m(5)U1939 and psi2504, in Escherichia coli 23S rRNA (2010), Biochem. Biophys. Res. Commun., 392, 223-227.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P55135 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + uracil1939 in 23S rRNA | - |
Escherichia coli | S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA | - |
? |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | strains lacking the RumA methylase are gradually out-competed by wild type strains in growth competition experiments, suggesting that the m5U methylation improves ribosome performance. Base substitutions at U1939 in 23S rRNA have little effect on growth or the fidelity of translation, but alter the sensitivity of the ribosomes to the antibiotics fusidic acid and capreomycin | Escherichia coli |
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Release 2023.1 (January 2023)
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