Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.188 extracted from

  • Takaya, A.; Sato, Y.; Shoji, T.; Yamamoto, T.
    Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible (2013), Antimicrob. Agents Chemother., 57, 3789-3796.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.188

Protein Variants

Protein Variants Comment Organism
A135T inactive Streptococcus pneumoniae
C23R inactive Streptococcus pneumoniae
C36R inactive Streptococcus pneumoniae
L113P inactive Streptococcus pneumoniae
L164P inactive Streptococcus pneumoniae
L165P inactive Streptococcus pneumoniae
L247P inactive Streptococcus pneumoniae
R200C inactive Streptococcus pneumoniae
Y212C inactive Streptococcus pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31500
-
 x * 31500, calculated from amino acid sequence Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine748 in 23S rRNA Streptococcus pneumoniae
-
 S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
-
 ?
S-adenosyl-L-methionine + guanine748 in 23S rRNA Streptococcus pneumoniae S1
-
 S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-
Streptococcus pneumoniae S1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine748 in 23S rRNA
-
 Streptococcus pneumoniae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
-
 ?
S-adenosyl-L-methionine + guanine748 in 23S rRNA
-
 Streptococcus pneumoniae S1 S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
-
 ?

Subunits

Subunits Comment Organism
? x * 31500, calculated from amino acid sequence Streptococcus pneumoniae

Synonyms

Synonyms Comment Organism
RlmAII
-
 Streptococcus pneumoniae
TlrB
-
 Streptococcus pneumoniae

General Information

General Information Comment Organism
malfunction the inactivation of the enzyme confers telithromycin resistance Streptococcus pneumoniae
physiological function methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible Streptococcus pneumoniae