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Literature summary for 2.1.1.188 extracted from

  • Lebars, I.; Husson, C.; Yoshizawa, S.; Douthwaite, S.; Fourmy, D.
    Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II) (2007), J. Mol. Biol., 372, 525-534.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
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-
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Purification (Commentary)

Purification (Comment) Organism
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Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine748 in 23S rRNA progressive truncation of the rRNA substrate indicates that multiple contacts occur between RlmAII and nucleotides in stem–loops 33, 34 and 35. RlmAII appears to recognize its rRNA target through specific surface shape complementarity at the junction formed by these three helices Streptococcus pneumoniae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
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Synonyms

Synonyms Comment Organism
RlmA(II)
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Streptococcus pneumoniae
tylosin resistance methyltransferase RlmA(II)
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Streptococcus pneumoniae