Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine748 in 23S rRNA | Streptomyces fradiae | the methyltransferase RlmAII (TlrB) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. The resistance conferred by RlmAII is highly specific for tylosin, and no resistance is conferred to other macrolide drugs, or to lincosamide and streptogramin B drugs that bind to the same region on the bacterial ribosome | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces fradiae | Q9S1M6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine748 in 23S rRNA | the methyltransferase RlmAII (TlrB) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. The resistance conferred by RlmAII is highly specific for tylosin, and no resistance is conferred to other macrolide drugs, or to lincosamide and streptogramin B drugs that bind to the same region on the bacterial ribosome | Streptomyces fradiae | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? | |
S-adenosyl-L-methionine + guanine748 in 23S rRNA | the methylation site of RlmAII is identified by liquid chromatography/electrospray ionization mass spectrometry as the N-1 position of 23S rRNA nucleotide G748 | Streptomyces fradiae | S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RlmA(II) | - |
Streptomyces fradiae |
RlmAII | - |
Streptomyces fradiae |
TlrB | - |
Streptomyces fradiae |
tylosin-resistance methyltransferase RlmA(II) | - |
Streptomyces fradiae |