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Literature summary for 2.1.1.182 extracted from

  • Binet, R.; Maurelli, A.T.
    The chlamydial functional homolog of KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness (2009), BMC Microbiol., 9, 279.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the presence of a functional rRNA dimethylase enzyme belonging to the KsgA family in Chlamydia present an excellent chemotherapeutic target Chlamydia trachomatis

Cloned(Commentary)

Cloned (Comment) Organism
-
Chlamydia psittaci
expression of the Chlamydia trachomatis L2 KsgA ortholog restored kasugamycin sensitivity to the Escherichia coli ksgA mutant Chlamydia trachomatis

Organism

Organism UniProt Comment Textmining
Chlamydia psittaci C7EP45
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-
Chlamydia psittaci 6BC C7EP45
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-
Chlamydia trachomatis B0B7S3
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-
Chlamydia trachomatis L2 B0B7S3
-
-

Synonyms

Synonyms Comment Organism
KsgA
-
Chlamydia trachomatis

General Information

General Information Comment Organism
malfunction mutants which contain a frameshift mutation in ksgA are severely impaired for growth Chlamydia trachomatis
physiological function KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness Chlamydia trachomatis