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Literature summary for 2.1.1.180 extracted from

  • Koscinski, L.; Feder, M.; Bujnicki, J.M.
    Identification of a missing sequence and functionally important residues of 16S rRNA:m(1)A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics (2007), Cell Cycle, 6, 1268-1271.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
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gene sequence is used for protein structure prediction, model of ShKamB Streptoalloteichus hindustanus

Organism

Organism UniProt Comment Textmining
Streptoalloteichus hindustanus Q2MEY3
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Synonyms

Synonyms Comment Organism
16S rRNA:m(1)A1408 methyltransferase
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Streptoalloteichus hindustanus
KamB
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Streptoalloteichus hindustanus
ShKam
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Streptoalloteichus hindustanus

General Information

General Information Comment Organism
physiological function microorganisms that produce aminoglycosides have developed a special mechanism of high level resistance by posttranscriptional methylation of 16S rRNA in the aminoglycoside binding site. N1-methylation of A1408 confers resistance to kanamycin, tobramycin, sisomycin and apramycin, but not to gentamycin. The M1A1408 methylation is carried out by methyltransferases from the Kam family Streptoalloteichus hindustanus