Any feedback?
Literature summary for 2.1.1.179 extracted from
- Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update (2012), Drug Resist. Updat., 15, 133-148.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Micromonospora zionensis |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Micromonospora echinospora |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Proteus mirabilis |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Micromonospora inyonensis |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Streptoalloteichus hindustanus |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Streptomyces kanamyceticus |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Serratia marcescens |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Pseudomonas aeruginosa |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Citrobacter freundii |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Micromonospora olivasterospora |
| drug development | development of potent agents against 16S-RMTase producers as targets for treatment of multidrug resistant bacteria | Micromonospora rosea |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene fmrO, phylogenetic analysis, sequence comparisons | Micromonospora olivasterospora |
| gene grmA, phylogenetic analysis, sequence comparisons | Micromonospora echinospora |
| gene grmB, phylogenetic analysis, sequence comparisons | Micromonospora rosea |
| gene kmr, phylogenetic analysis, sequence comparisons | Streptomyces kanamyceticus |
| gene nbrB, phylogenetic analysis, sequence comparisons | Streptoalloteichus hindustanus |
| gene rmtA, phylogenetic analysis, sequence comparisons | Pseudomonas aeruginosa |
| gene rmtB, phylogenetic analysis, sequence comparisons | Serratia marcescens |
| gene rmtC, phylogenetic analysis, sequence comparisons | Proteus mirabilis |
| gene rmtD2, phylogenetic analysis, sequence comparisons | Citrobacter freundii |
| gene sgm, phylogenetic analysis, sequence comparisons | Micromonospora zionensis |
| gene smr1, phylogenetic analysis, sequence comparisons | Micromonospora inyonensis |
| phylogenetic analysis, sequence comparisons | Pseudomonas aeruginosa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Micromonospora zionensis | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? |  |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Micromonospora echinospora | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Proteus mirabilis | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Micromonospora inyonensis | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Streptoalloteichus hindustanus | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Streptomyces kanamyceticus | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Serratia marcescens | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Pseudomonas aeruginosa | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Citrobacter freundii | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Micromonospora olivasterospora | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Micromonospora rosea | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | Proteus mirabilis ARS68 | - |
S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Citrobacter freundii | E9N3S1 | RmtD2; gene rmtD2 | - |
| Micromonospora echinospora | Q70KC8 | GrmA; gene grmA | - |
| Micromonospora inyonensis | Q5Y813 | Smr1; gene smr1 | - |
| Micromonospora olivasterospora | Q08325 | FmrO; gene fmrO | - |
| Micromonospora rosea | P24619 | GrmB; gene grmB | - |
| Micromonospora zionensis | Q7M0R2 | Sgm; gene sgm | - |
| Proteus mirabilis | Q33DX5 | RmtC; gene rmtC | - |
| Proteus mirabilis ARS68 | Q33DX5 | RmtC; gene rmtC | - |
| Pseudomonas aeruginosa | A0MK31 | RmtD; gene rmtD | - |
| Pseudomonas aeruginosa | Q8GRA1 | RmtA; gene rmtA | - |
| Serratia marcescens | Q76G15 | RmtB; gene rmtB | - |
| Streptoalloteichus hindustanus | O52472 | NbrB; gene nbrB | - |
| Streptomyces kanamyceticus | Q75PS4 | Kmr; gene kmr | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Micromonospora zionensis | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Micromonospora echinospora | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Proteus mirabilis | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Micromonospora inyonensis | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Streptoalloteichus hindustanus | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Streptomyces kanamyceticus | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Serratia marcescens | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Pseudomonas aeruginosa | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Citrobacter freundii | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Micromonospora olivasterospora | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Micromonospora rosea | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
| S-adenosyl-L-methionine + cytosine1405 in 16S rRNA | - |
Proteus mirabilis ARS68 | S-adenosyl-L-homocysteine + 5-methylcytosine1405 in 16S rRNA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 16S rRNA methyltransferase | - |
Micromonospora zionensis |
| 16S rRNA methyltransferase | - |
Micromonospora echinospora |
| 16S rRNA methyltransferase | - |
Proteus mirabilis |
| 16S rRNA methyltransferase | - |
Micromonospora inyonensis |
| 16S rRNA methyltransferase | - |
Streptoalloteichus hindustanus |
| 16S rRNA methyltransferase | - |
Streptomyces kanamyceticus |
| 16S rRNA methyltransferase | - |
Serratia marcescens |
| 16S rRNA methyltransferase | - |
Pseudomonas aeruginosa |
| 16S rRNA methyltransferase | - |
Citrobacter freundii |
| 16S rRNA methyltransferase | - |
Micromonospora olivasterospora |
| 16S rRNA methyltransferase | - |
Micromonospora rosea |
| 16S-RMTase | - |
Micromonospora zionensis |
| 16S-RMTase | - |
Micromonospora echinospora |
| 16S-RMTase | - |
Proteus mirabilis |
| 16S-RMTase | - |
Micromonospora inyonensis |
| 16S-RMTase | - |
Streptoalloteichus hindustanus |
| 16S-RMTase | - |
Streptomyces kanamyceticus |
| 16S-RMTase | - |
Serratia marcescens |
| 16S-RMTase | - |
Pseudomonas aeruginosa |
| 16S-RMTase | - |
Citrobacter freundii |
| 16S-RMTase | - |
Micromonospora olivasterospora |
| 16S-RMTase | - |
Micromonospora rosea |
| FmrO | - |
Micromonospora olivasterospora |
| GrmA | - |
Micromonospora echinospora |
| GrmB | - |
Micromonospora rosea |
| Kmr | - |
Streptomyces kanamyceticus |
| N7-G1405 16S-RMTase | - |
Micromonospora zionensis |
| N7-G1405 16S-RMTase | - |
Micromonospora echinospora |
| N7-G1405 16S-RMTase | - |
Proteus mirabilis |
| N7-G1405 16S-RMTase | - |
Micromonospora inyonensis |
| N7-G1405 16S-RMTase | - |
Streptoalloteichus hindustanus |
| N7-G1405 16S-RMTase | - |
Streptomyces kanamyceticus |
| N7-G1405 16S-RMTase | - |
Serratia marcescens |
| N7-G1405 16S-RMTase | - |
Pseudomonas aeruginosa |
| N7-G1405 16S-RMTase | - |
Citrobacter freundii |
| N7-G1405 16S-RMTase | - |
Micromonospora olivasterospora |
| N7-G1405 16S-RMTase | - |
Micromonospora rosea |
| NbrB | - |
Streptoalloteichus hindustanus |
| RmtA | - |
Pseudomonas aeruginosa |
| RmtB | - |
Serratia marcescens |
| RmtC | - |
Proteus mirabilis |
| RmtD | - |
Pseudomonas aeruginosa |
| RmtD2 | - |
Citrobacter freundii |
| sgm | - |
Micromonospora zionensis |
| Smr1 | - |
Micromonospora inyonensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Micromonospora zionensis | |
| S-adenosyl-L-methionine | - |
Micromonospora echinospora | |
| S-adenosyl-L-methionine | - |
Proteus mirabilis | |
| S-adenosyl-L-methionine | - |
Micromonospora inyonensis | |
| S-adenosyl-L-methionine | - |
Streptoalloteichus hindustanus | |
| S-adenosyl-L-methionine | - |
Streptomyces kanamyceticus | |
| S-adenosyl-L-methionine | - |
Serratia marcescens | |
| S-adenosyl-L-methionine | - |
Pseudomonas aeruginosa | |
| S-adenosyl-L-methionine | - |
Citrobacter freundii | |
| S-adenosyl-L-methionine | - |
Micromonospora olivasterospora | |
| S-adenosyl-L-methionine | - |
Micromonospora rosea | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | FmrO shows intrinsic N7-G1405 16S-RMTase activity | Micromonospora olivasterospora |
| evolution | RmtA shows aquired N7-G1405 16S-RMTase activity | Pseudomonas aeruginosa |
| evolution | RmtB shows aquired N7-G1405 16S-RMTase activity | Serratia marcescens |
| evolution | RmtC shows aquired N7-G1405 16S-RMTase activity | Proteus mirabilis |
| evolution | RmtD shows aquired N7-G1405 16S-RMTase activity | Pseudomonas aeruginosa |
| evolution | RmtD2 shows aquired N7-G1405 16S-RMTase activity | Citrobacter freundii |
| additional information | GrmA shows intrinsic N7-G1405 16S-RMTase activity | Micromonospora echinospora |
| additional information | GrmB shows intrinsic N7-G1405 16S-RMTase activity | Micromonospora rosea |
| additional information | Kmr shows intrinsic N7-G1405 16S-RMTase activity | Streptomyces kanamyceticus |
| additional information | NbrB shows intrinsic N7-G1405 16S-RMTase activity | Streptoalloteichus hindustanus |
| additional information | Sgm shows intrinsic N7-G1405 16S-RMTase activity | Micromonospora zionensis |
| additional information | Smr1 shows intrinsic N7-G1405 16S-RMTase activity | Micromonospora inyonensis |
| physiological function | most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis, These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Micromonospora olivasterospora |
| physiological function | most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Micromonospora zionensis |
| physiological function | most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Micromonospora echinospora |
| physiological function | most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Micromonospora inyonensis |
| physiological function | most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Streptoalloteichus hindustanus |
| physiological function | most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Streptomyces kanamyceticus |
| physiological function | most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Micromonospora rosea |
| physiological function | the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Proteus mirabilis |
| physiological function | the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Serratia marcescens |
| physiological function | the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Citrobacter freundii |
| physiological function | the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Pseudomonas aeruginosa clinical isolates show high-level resistance to clinically useful aminoglycosides through the production of acquired 16S-RMTase. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview | Pseudomonas aeruginosa |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
