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Literature summary for 2.1.1.179 extracted from

  • Wachino, J.; Shibayama, K.; Kimura, K.; Yamane, K.; Suzuki, S.; Arakawa, Y.
    RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms (2010), FEMS Microbiol. Lett., 311, 56-60.
    View publication on PubMed
Search for more literature for 2.1.1.179

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, Bacillus subtilis or Staphylococcus aureus Proteus mirabilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Proteus mirabilis RmtC can confer high-level resistance to gentamicin and kanamycin in Bacillus subtilis and Staphylococcus aureus S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
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 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA Proteus mirabilis ARS68 RmtC can confer high-level resistance to gentamicin and kanamycin in Bacillus subtilis and Staphylococcus aureus S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Proteus mirabilis Q33DX5 plasmid-mediated methyltransferase
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Proteus mirabilis ARS68 Q33DX5 plasmid-mediated methyltransferase
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Purification (Commentary)

Purification (Comment) Organism
-
 Proteus mirabilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine1405 in 16S rRNA RmtC can confer high-level resistance to gentamicin and kanamycin in Bacillus subtilis and Staphylococcus aureus Proteus mirabilis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA RmtC has an MTase activity specific for the bacterial 30S ribosomal subunit consisting of 16S rRNA and several ribosomal proteins, but not for the naked 16S rRNA Proteus mirabilis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA RmtC can confer high-level resistance to gentamicin and kanamycin in Bacillus subtilis and Staphylococcus aureus Proteus mirabilis ARS68 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
S-adenosyl-L-methionine + guanine1405 in 16S rRNA RmtC has an MTase activity specific for the bacterial 30S ribosomal subunit consisting of 16S rRNA and several ribosomal proteins, but not for the naked 16S rRNA Proteus mirabilis ARS68 S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
RmtC
-
 Proteus mirabilis