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Literature summary for 2.1.1.172 extracted from

  • Sergiev, P.V.; Bogdanov, A.A.; Dontsova, O.A.
    Ribosomal RNA guanine-(N2)-methyltransferases and their targets (2007), Nucleic Acids Res., 35, 2295-2301.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine1207 in 16S rRNA Escherichia coli RsmD methyltransferase utilizes assembled ribosomal small subunit or its late assembly intermediates as a substrate. It is likely it uses the decoding cleft of the small subunit as the binding site. Nucleotide N2-methylguanine1207 is located in the helix 34 of the 16S rRNA. This functionally important helix is involved in the formation of the binding pocket for A-site bound tRNA and translocation. Despite location in the very functionally important region of the 30S subunit, N2-methylguanine1207 is not involved in the contact with tRNA. Methylation of G1207 may be necessary to freeze secondary structure in the functional conformation S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
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Organism

Organism UniProt Comment Textmining
Escherichia coli P39406
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine1207 in 16S rRNA
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Escherichia coli S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
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S-adenosyl-L-methionine + guanine1207 in 16S rRNA RsmD methyltransferase utilizes assembled ribosomal small subunit or its late assembly intermediates as a substrate. It is likely it uses the decoding cleft of the small subunit as the binding site. Nucleotide N2-methylguanine1207 is located in the helix 34 of the 16S rRNA. This functionally important helix is involved in the formation of the binding pocket for A-site bound tRNA and translocation. Despite location in the very functionally important region of the 30S subunit, N2-methylguanine1207 is not involved in the contact with tRNA. Methylation of G1207 may be necessary to freeze secondary structure in the functional conformation Escherichia coli S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
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Synonyms

Synonyms Comment Organism
RsmC
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Escherichia coli
yjjT
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Escherichia coli