Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine1207 in 16S rRNA | Escherichia coli | RsmD methyltransferase utilizes assembled ribosomal small subunit or its late assembly intermediates as a substrate. It is likely it uses the decoding cleft of the small subunit as the binding site. Nucleotide N2-methylguanine1207 is located in the helix 34 of the 16S rRNA. This functionally important helix is involved in the formation of the binding pocket for A-site bound tRNA and translocation. Despite location in the very functionally important region of the 30S subunit, N2-methylguanine1207 is not involved in the contact with tRNA. Methylation of G1207 may be necessary to freeze secondary structure in the functional conformation | S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P39406 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + guanine1207 in 16S rRNA | - |
Escherichia coli | S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA | - |
? | |
S-adenosyl-L-methionine + guanine1207 in 16S rRNA | RsmD methyltransferase utilizes assembled ribosomal small subunit or its late assembly intermediates as a substrate. It is likely it uses the decoding cleft of the small subunit as the binding site. Nucleotide N2-methylguanine1207 is located in the helix 34 of the 16S rRNA. This functionally important helix is involved in the formation of the binding pocket for A-site bound tRNA and translocation. Despite location in the very functionally important region of the 30S subunit, N2-methylguanine1207 is not involved in the contact with tRNA. Methylation of G1207 may be necessary to freeze secondary structure in the functional conformation | Escherichia coli | S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA | - |
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Synonyms | Comment | Organism |
---|---|---|
RsmC | - |
Escherichia coli |
yjjT | - |
Escherichia coli |