Literature summary for 2.1.1.170 extracted from

Tanaka, Y.; Tokuyama, S.; Ochi, K.
Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus (2009), J. Antibiot., 62, 669-673.

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces griseus	-	IFO13189	-
Streptomyces griseus IFO13189	-	IFO13189	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + guanine527 in 16S rRNA	the methyltransferase RsmG methylates the N7 position of nucleotide G535 in 16S rRNA of Bacillus subtilis (corresponding to G527 in Escherichia coli)	Streptomyces griseus	S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA	-	?
S-adenosyl-L-methionine + guanine527 in 16S rRNA	the methyltransferase RsmG methylates the N7 position of nucleotide G535 in 16S rRNA of Bacillus subtilis (corresponding to G527 in Escherichia coli)	Streptomyces griseus IFO13189	S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA	-	?

General Information

General Information	Comment	Organism
malfunction	the rsmG mutants show impaired ability to form aerial mycelia, and are somewhat deficient in sporulation. rsmG mutants show greater ability (two- to threefold) to produce streptomycin. The rsmG mutant exhibits elevated levels of metK, strR, strB1, strF and strD expression compared with the wild-type strain at late growth phase (36 h), thus underlying the enhanced production of streptomycin in the rsmG mutant. rsmG mutation is effective not only for enhancement of streptomycin production but also for activation of silent or poorly expressed genes in Streptomyces griseus	Streptomyces griseus

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Release 2023.1 (January 2023)