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Literature summary for 2.1.1.17 extracted from

  • Kobayashi, S.; Mizuike, A.; Horiuchi, H.; Fukuda, R.; Ohta, A.
    Mitochondrially-targeted bacterial phosphatidylethanolamine methyltransferase sustained phosphatidylcholine synthesis of a Saccharomyces cerevisiae DELTApem1 DELTApem2 double mutant without exogenous choline supply (2014), Biochim. Biophys. Acta, 1841, 1264-1271.
    View publication on PubMed

Application

Application Comment Organism
analysis development of A system that transports phosphatidylethanolamine to the mitochondria where it is methylated to phosphatidylcholine and phosphatidylcholine is transported back to other organelles and supports the growth of the mutants defective in phosphatidylcholine synthesis Acetobacter aceti

Organism

Organism UniProt Comment Textmining
Acetobacter aceti
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Acetobacter aceti NBRC 3283
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General Information

General Information Comment Organism
physiological function recombinant expression of phosphatidylethanolamine methyltransferase from Acetobacter aceti, fused with a mitochondrial targeting signal from yeast, in Saccharomyces cerevisiae. The expression suppresses the choline auxotrophy of a double deletion mutant of endogenous phosphatidylethanolamine methyltransferases PEM1 and PEM2 and enables synthesis of phosphatidylcholine in the absence of choline. This growth suppression is observed even if the Kennedy pathway is inactivated by the repression of PCT1 encoding CTP:phosphocholine cytidylyltransferase Acetobacter aceti