Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphatidylethanolamine, monomethyl-phosphatidylethanolamine and dimethyl-phosphatidylethanolamine compete for a common active site | Rattus norvegicus | |
S-adenosylhomocysteine | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
S-adenosylmethionine | reaction with phosphatidyl-N,N-dimethylethanolamine | Rattus norvegicus | |
0.022 | - |
S-adenosylmethionine | reaction with phosphatidyl-N-monomethylethanolamine | Rattus norvegicus | |
0.08 | - |
phosphatidyl-N-methylethanolamine | - |
Rattus norvegicus | |
0.45 | - |
phosphatidyl-N,N-dimethylethanolamine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
18300 | - |
1 * 18300, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.63 | - |
activity with phosphatidylethanolamine | Rattus norvegicus |
3.75 | - |
activity with phosphatidyl-N-monomethylethanolamine | Rattus norvegicus |
8.59 | - |
activity with phosphatidyl-N,N-dimethyl-ethanolamine | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine | ordered bi-bi mechanism | Rattus norvegicus | 2 S-adenosyl-L-homocysteine + phosphatidylcholine | - |
? | |
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine | - |
Rattus norvegicus | S-adenosyl-L-methionine + phosphatidylethanolamin | - |
? | |
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine | ordered bi-bi mechanism | Rattus norvegicus | S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine | - |
? | |
S-adenosyl-L-methionine + phosphatidylethanolamine | transfer of three methyl groups to the amino head group of phosphatidylethanolamine | Rattus norvegicus | S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 18300, SDS-PAGE | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
activity increases in nearly a linear fashion between pH 6.0 and 9.5 | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0049 | - |
S-adenosyl-L-homocysteine | reaction with phosphatidyl-N-monomethylethanolamine | Rattus norvegicus | |
0.0067 | - |
S-adenosyl-L-homocysteine | reaction with phosphatidyl-N,N-dimethylethanolamine | Rattus norvegicus | |
0.0739 | - |
S-adenosylhomocysteine | reaction with phosphatidyl-N-dimethylethanolamine | Rattus norvegicus |