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Literature summary for 2.1.1.148 extracted from

  • Ulmer, J.E.; Boum, Y.; Thouvenel, C.D.; Myllykallio, H.; Sibley, C.H.
    Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif (2008), J. Bacteriol., 190, 2056-2064.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information analysis of 67 site-directed mutants and identification of the extended motif Y44X(24)H69X(25)R95HRX(87)S105XRYX(90)R199 of amino acids essential to enzyme activity. Residue H69 is the catalytic residue, S105 the nucleophile Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WG57
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Mycobacterium tuberculosis H37Rv P9WG57
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