Literature summary for 2.1.1.148 extracted from

Mason, A.; Agrawal, N.; Washington, M.T.; Lesley, S.A.; Kohen, A.
A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link (2006), Chem. Commun. (Camb. ), 16, 1781-1783.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0122	-	dUMP	at 80 °C	Thermotoga maritima

Organism

Organism	UniProt	Comment	Textmining
Thermotoga maritima	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP + FADH2	dUMP dependent lag-phase for the single turnover reduction of FDTS bound FAD by NADPH	Thermotoga maritima	dTMP + tetrahydrofolate + FAD	-	?

Synonyms

Synonyms	Comment	Organism
FDTS	-	Thermotoga maritima
flavin dependent thymidylate synthase	-	Thermotoga maritima

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Thermotoga maritima

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Release 2023.1 (January 2023)