Application | Comment | Organism |
---|---|---|
medicine | the unique mechanism of FDTS makes it an attractive target for antibiotic drug development | Thermotoga maritima |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Thermotoga maritima |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Thermotoga maritima | the enzyme is essential to DNA replication | ? | - |
? | |
additional information | Thermotoga maritima DSM 3109 | the enzyme is essential to DNA replication | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermotoga maritima | Q9WYT0 | TM0449 | - |
Thermotoga maritima DSM 3109 | Q9WYT0 | TM0449 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is essential to DNA replication | Thermotoga maritima | ? | - |
? | |
additional information | the enzyme is essential to DNA replication | Thermotoga maritima DSM 3109 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FDTS | - |
Thermotoga maritima |
flavin-dependent TS | - |
Thermotoga maritima |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | the pro-R hydride of NADPH and not the R6 hydride of the tetrahydropterin is the reducing agent. The stereospecificity for the pro-R NADPH oxidation is not absolute. The hydride is transferred to FAD, which is the rate-limiting step of the catalytic cascade | Thermotoga maritima | |
NADPH | the pro-R hydride of NADPH and not the R6 hydride of the tetrahydropterin is the reducing agent. The stereospecificity for the pro-R NADPH oxidation is not absolute. The hydride is transferred to FAD, which is the rate-limiting step of the catalytic cascade | Thermotoga maritima |