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Literature summary for 2.1.1.145 extracted from

  • Katz, J.E.; Dumlao, D.S.; Wasserman, J.I.; Lansdown, M.G.; Jung, M.E.; Faull, K.F.; Clarke, S.
    3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase (2004), Biochemistry, 43, 5976-5986.
    View publication on PubMed
Search for more literature for 2.1.1.145

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019
-
 2-(1-methylethylidine)succinate
-
 Saccharomyces cerevisiae
0.045
-
 3-butylmalate
-
 Saccharomyces cerevisiae
0.053
-
 trans-aconitate
-
 Saccharomyces cerevisiae
0.127
-
 (2R,3S)-3-isopropylmalate
-
 Saccharomyces cerevisiae
0.323
-
 isopropylmaleate
-
 Saccharomyces cerevisiae
0.341
-
 (2S,3R)-3-isopropylmalate
-
 Saccharomyces cerevisiae
0.428
-
 (2R,3R)/(2S,3S)-3-isopropylmalate
-
 Saccharomyces cerevisiae
1.67
-
 isopropylfumarate
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the enzyme may work in two different pathways in two different ways: for detoxification in the citric acid cycle and for a possibly novel biosynthetic branch reaction of the leucine biosynthetic pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme may work in two different pathways in two different ways: for detoxification in the citric acid cycle and for a possibly novel biosynthetic branch reaction of the leucine biosynthetic pathway Saccharomyces cerevisiae ?
-
 ?
additional information no activity as substrate: 2-isopropylmalate Saccharomyces cerevisiae ?
-
 ?
S-adenosyl-L-methionine + (2R,3R)/(2S,3S)-3-isopropylmalate poor substrate Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + (2R,3S)-3-isopropylmalate
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + (2S,3R)-3-isopropylmalate
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + 2-(1-methylethylidine)succinate
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + 3-butylmalate
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + isopropylfumarate poor substrate Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + isopropylmaleate
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + trans-aconitate
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate
-
 ?

Synonyms

Synonyms Comment Organism
Tmt1 methyltransferase
-
 Saccharomyces cerevisiae