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Literature summary for 2.1.1.137 extracted from

  • Wang, S.; Geng, Z.; Shi, N.; Li, X.; Wang, Z.
    The functions of crucial cysteine residues in the arsenite methylation catalyzed by recombinant human arsenic (III) methyltransferase (2014), PLoS ONE, 9, e110924.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) pLysS cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C250S the mutation favors S-adenosyl-L-methionine binding to the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + arsenite Homo sapiens
-
S-adenosyl-L-homocysteine + methylarsonate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HBK9
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + arsenite
-
Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
?

Synonyms

Synonyms Comment Organism
arsenic (III) methyltransferase
-
Homo sapiens
AS3MT
-
Homo sapiens